When it was discovered that the human body contains endocannabinoid receptors, and that cannabinoids found in marijuana - like THC, CBD, and THCA - organically attach to these receptors, much like aspirin, it opened up a whole new world for medical cannabis.
Now, in collaboration with the CESC (Clinical Endocannabinoid System Consortium), a nonprofit research group, MediCann is in a unique position to better understand the efficacy of cannabis. We know it has proven health benefits, but what types of strains best treat which conditions? What is the most effective dosage? Mode of administration? When is it best to take it? These are all common questions a physician asks when prescribing medicine for a patient's condition.
The Dosing Project is CESC’s flagship clinical study that establishes, in milligrams per kilograms, important dosage information from patient data. It establishes what cannabis plants and products are best for sleep, pain, inflammation, and any other medical condition for which cannabis is used. We’re finding out how different strains treat different conditions in patients. In addition, the CESC is developing strain nomenclature and analyzing plot sampling methods that will move cannabis cultivation for medicine rapidly into the future. This clinical study will improve the efficacy of cannabis for all patients, present and future.
Participation as a patient in The Dosing Project study is FREE and is protected under HIPAA privacy laws. Click Here to Join The Dosing Project Study
If you or your organization would like to sponsor or become a member of the Dosing Project, click here.
MediCann physicians have the unique opportunity to hear about a person’s experience using cannabis. We can document pain, evaluate anxiety, and review sleep patterns and assess how well cannabis works to improve these symptoms. Gone are the days of sharing myths with someone you don’t know or don’t want to tell that you use cannabis. Cannabis today is accessible, varied, and abundant. As medicine, it’s not just a plant. It’s a capsule, a tincture, an oil, a salve, or ointment. Although the use of cannabis is old, the medical cannabis industry is young. We are just learning about different strains and which to use. Which cannabis helps you sleep? Which is best for pain? Rather than rely on a here today, gone tomorrow individual who is illegally selling cannabis, patients now depend on a knowledgeable physician and knowledgeable dispensary service. That state of California enacted the California’s Medical Cannabis Regulation and Safety Act (MCRSA), on January 1, 2016, to be implemented in January 1, 2018. The act calls for factions of the cannabis industry to apply for specific licenses and follow stated regulations. It brings the young medical cannabis industry one step away from a sneaky purchase in a dark corner of the downtown park and one step closer to safe, clean and natural medicine.
What does this mean from the patient perspective? For one thing, if you have your own garden, you can continue to grow your own medicinal plants. The new California law allows patients to grow up to 100 square feet of plants. If you grow for patients as their “caregiver”, you have to limit your garden to 500 square feet and serve 5 or fewer patients. For the many of us who don’t have our own garden, dispensaries will continue to be available. Dispensaries will receive their cannabis products from state licensed commercial cultivators and manufacturers. All cannabis will go through mandatory testing and placed in tamper proof packaging. In contrast to the upcoming vote for “adult use”, California’s MCRSA law is already in place with specific regulations being developed. Whether Prop. 64 passes or not, medical cannabis will become available in California in better form and as better medicine.
Sativa vs Indica...
After attending one of MediCann’s Affiliate Physician offices, a patient receives a recommendation letter (similar to prescription) that allows you to purchase your cannabis medicine at a dispensary (similar to pharmacy). The noticeable difference is that the recommendation letter doesn’t tell you what to use or how much to use. Medical studies have yet to verify appropriate strains and appropriate doses for specific indication. When you arrive at a medical cannabis dispensary, your letter will be verified at the entrance and then you’ll be directed to a counter displaying multiple dried cannabis flowers with different names. Outside of the name, a standard distinction between cannabis products is “Sativa”, “Indica” or a hybrid of both. The reality is that all cannabis plants have been hybridized. Some display a thin leafed “Sativa” trait and others have the broader leafed “Indica” trait. Pearce et al published a survey among medical cannabis users in the Journal of Alternative and Complementary Medicine, finding that “Indica” is best for pain and sleep while “Sativa” increased energy and improved mood. The study concluded that there was a difference in effect, but could not identify whether the shape of leaf or THC/CBD ratio was the source of that difference.
Dr. John Abrams, Chairman and Chief Science Officer of the Clinical Endocannabinoid System Consortium (CESC) proposes a chemical difference between strains. After sampling 686 plants, he noted three distinct chemical types based on THC/CBD ratio. Does this identify the “Sativa”, “Indica” and hybrid effect? Dr. Abrams plans to find out as he launches the CESC’s first clinical study, The Dosing Project (http://www.thecesc.org/the-dosing-project). The study aims to discover the chemical types of cannabis that improve sleep and reduce pain.
The myth among cannabis users suggests a “Sativa” effect and “Indica” effect. The person behind the counter at your local medical cannabis dispensary will launch into an explanation of “Sativa” flower and how it gives a mood uplifting, non-drowsy effect. In contrast, the description of “Indica” flower includes a sedating and pain reduction effect. Can you rely on this information? Probably, yes. Since there is not a scientific way to distinguish “Sativa” vs “Indica” other than the shape of the leaf, my guess is that the dispensary staff is sampling their products and concluding the distinction through experience. Errors in distinction are covered up by adding categories. Some dispensaries describe an “Indica” dominant - “Sativa” hybrid or a “Sativa” dominant - “Indica” hybrid. Research is slow and methodical for a reason. We want to come to the right conclusion. As Dr. Abrams pursues the truth, we wait and do the best we can. Buy small amounts. Experiment and observe. “Sativa” or “Indica”? Your call. If it works, it works.
 Pearce, et al. Discriminating the Effects of Cannabis Sativa and Cannabis Indica: A Web Survey of Medical Cannabis Users. The Journal of Alternative and Complementary Medicine. Volume 20, Number 10, 2014, pp. 787-791
Times are changing...
Since MediCann first opened its offices to the community, our providers have always been convinced of the medical efficacy of cannabis. Over the last 12 years, MediCann has seen the number of states joining the movement grow from 5 to 25 plus Washington D.C. The list of organizations that support medical cannabis include, the American Academy of Family Physicians, the American Nurses Association, the American Osteopathic Association, the American Preventive Medical Association, the American Public Health Association, the American Society of Addiction Medicine, the Lymphoma Foundation of America, The Montel Williams MS Foundation, Kaiser Permanente, the New England Journal of Medicine, and many more. High profile physicians, such as Dr. Sanjay Gupta, Dr. Dean Edell, and Dr. Andrew Weil also support cannabis for certain conditions. Those who continue to scoff at the potential of cannabis to help are simply without access to appropriate information or resource. Our discussion has changed from “Does cannabis help?” to “What does cannabis help?” The new MediCann would like to present itself as an intermediary to information and resources on the use of cannabis as medicine.
With greater acceptance comes greater responsibility…
Now, more than ever, there are so many questions. “Does it really cure cancer?” Can I use it and not get “high”? The many years of prohibition left vital questions unanswered. Science has eighty years of inactivity to overcome. MediCann takes on the responsibility of investigating some of the answers through its association with the Clinical Endocannabinoid System Consortium (The CESC), a non profit research organization and the launch of its flagship program, The Dosing Project. Additionally, MediCann educates patients on where to find the best cannabis preparations for their symptoms diagnosis through our new Medicine Locator. Our News and Events page will keep you up to date on the latest on the growing cannabis knowledge and industry. We still refer potential patients to top rated physicians who provide evaluations for optimal and legal medical cannabis use. Our Doctor Locator page provides you with contact information to assist in scheduling an appointment by phone or email.
Not everything changes….
Science has identified potential for anti-cancer, anti-inflammatory, anti-seizure, anesthetic, anti-diabetic, anti-anxiety, anti-depressant and sleep agents all from the chemical components of the cannabis plant. Pharmaceutical companies are preparing cannabis based medicines for sale and financial investors are placing their bets on the best cannabis product. Our grassroots movement has blossomed into a burgeoning industry. Yet, you can still grow it easily and inexpensively in your backyard. We have a lot more to know. Throughout its existence, MediCann has always supported patients. As MediCann brings you more information and resources, our fundamental mission will not change. We look forward to many years as your partner in cannabis and health.
Jean Talleyrand, M.D.,